Andriol, which is the brand name and trade name for Testosterone Undecanoate, is an oral Testosterone product. It is oil-based and manufactured in the form of gel capsules. It is vastly different from other oral anabolic steroids in a few different ways. First and foremost, other oral anabolic steroid products are almost always C-17 alpha alkylated (also known as methylation). This is a process whereby a methyl group is affixed to the 17th carbon on the Testosterone (or other anabolic steroid) compound, which allows the hormone to survive the first pass through the liver, thereby allowing it to be orally bioavailable so that the user can use it orally. The downside to this modification is that C-17 alpha alkylation almost always presents a degree of liver toxicity (hepatotoxicity) and strain, thereby limiting the length of use and/or maximum dosage. Andriol does not possess C-17 alpha alkylation despite it being an orally active form of Testosterone.
Instead, Andriol is an esterified form of Testosterone (Testosterone Undecanoate), whereby it is affixed to an extremely long fatty acid chain ester. Research has demonstrated that when Andriol is consumed (especially in the presence of dietary fats), the high lipophilic nature of it allows at least partial absorption via the body’s lymphatic system through the gastrointestinal tract. Although Andriol is not liver toxic at all, there are some disadvantages to its nature. Because it relies on fat solubility to be absorbed in the body, research has shown that Androl’s oral bioavailability is around 7%.
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